Smoothing grouped bivariate data to obtain the incubation period distribution of aids

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Smoothing grouped bivariate data to obtain the incubation period distribution of AIDS.

We use a penalized likelihood approach to obtain a smooth estimate of a bivariate distribution from grouped data where each observation consists of a region in a plane. The purpose of the analysis is to estimate the incubation period distribution of AIDS from the Multicenter AIDS Cohort Study, a prevalent cohort of homosexual men. In this article we illustrate the usefulness of the penalized li...

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This paper contains details of methods and full results of estimates of the incubation period of acquired immunodeficiency syndrome (AIDS) that were outlined in a previous paper by Medley et al. (Nature, Lond. 328, 719 (1987)). The original model is modified to assess the influence of age and sex on the incubation period: age, but not sex, is statistically significant. The difficulties associat...

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ژورنال

عنوان ژورنال: Statistics in Medicine

سال: 1994

ISSN: 0277-6715,1097-0258

DOI: 10.1002/sim.4780130907